Affiliation:
1. “Giorgio Fornaini” Institute of Biochemistry, University of Urbino, 61029 Urbino (PS), Italy
Abstract
ABSTRACT
Murine AIDS in C57BL/6 mice is caused by a unique mixture of murine leukemia viruses. We report the use of a competitive PCR to detect and quantitate BM5d proviral DNA. This assay allowed discrimination among endogenous wild-type murine retroviruses and BM5d sequences. Furthermore, the method was subsequently used to evaluate the amount of BM5d in infected mice and in infected AZT (zidovudine)-treated mice, providing an effective way to quantitatively evaluate drug efficacy in the murine AIDS model.
Publisher
American Society for Microbiology
Cited by
14 articles.
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