Comparison of Tobramycin, Gentamicin, Colistin, and Carbenicillin in Pseudomonas Sepsis in Monkeys

Author:

Saslaw Samuel1,Carlisle Harold N.1,Moheimani Mohammad1

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio 43210

Abstract

Intravenous inoculation of 3.4 × 10 10 to 7.4 × 10 10 Pseudomonas aeruginosa organisms into rhesus monkeys 4 days after intravenous or intratracheal inoculation of 2.0 to 2.5 mg of vincristine sulfate resulted in fatal sepsis in eight of nine monkeys. After intramuscular administration, in two equal doses, of 5 mg of tobramycin, gentamicin, and colistin per kg per day beginning 16 hr after challenge, 4 of 11, 4 of 11, and 3 of 10 monkeys died, respectively. Administration of daily doses of 100 to 400 mg of carbenicillin per kg was followed by death in 5 of 12. Duration of illness in the surviving monkeys in each therapy group was similar. Under the conditions of this study, prior administration of vincristine sulfate resulted in a decrease in leukocytes and enhanced susceptibility to Pseudomonas infection. Using this model for studies of comparative efficacy of antibiotics, we observed comparable results after treatment with tobramycin, gentamicin, colistin, and carbenicillin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference16 articles.

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2. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia;Bodey G. P.;Ann. Intern. Med.,1966

3. Bodey G. P. V. Rodriguez and J. P. Whitecar. 1969. Severe infections in leukemic patients-an approach to antibiotic therapy p. 65-78. In Advances in the management of Pseudomonas and Proteus infections. Excerpta Medica Foundation New York.

4. Pseudomonas bacteremia: review of ninety-one cases;Curtin J. A.;Ann. Intern. Med.,1961

5. Antibiotics for Pseudomonas aeruginosa sepsis: inadequate proof of efficacy;Davis S. D.;J. Infect. Dis.,1971

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