Failure of Phorbol Myristate Acetate to Damage DNA in Leukocytes from Patients with Chronic Granulomatous Disease

Author:

Birnboim H. C.1,Biggar W. D.2

Affiliation:

1. Atomic Energy of Canada Limited, Chalk River Nuclear Laboratories, Chalk River, Ontario K0J IJ0, Canada

2. Department of Pediatrics, Research Institute, The Hospital for Sick Children and University of Toronto, Toronto, Ontario M5G IX8, Canada

Abstract

Unlike leukocytes from normal donors, leukocytes from patients with chronic granulomatous disease do not suffer DNA damage on exposure to the tumor promoter, phorbol myristate acetate.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference8 articles.

1. Leukocyte oxidase: defective activity in chronic granulomatous disease;Baehner R. L.;Science,1967

2. DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate;Birnboim H. C.;Science,1982

3. Fluorometric method for rapid detection of DNA strand breaks in human white blood cells procured by low doses of radiation;Birnboim H. C.;Cancer Res.,1981

4. Defective superoxide production by granulocytes from patients with chronic granulomatous disease;Curnutte J. T.;N. EngI. J. Med.,1974

5. .Hecker E. N. E. Fusenig W. Kunz F. Marks and H. W. Thielmann (ed.). 1982. Carcinogenesis-a comprehensive survey vol. 7. Raven Press. New York.

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