Author:
Ebersole J L,Taubman M A,Smith D J
Abstract
The effect of T-cell depletion on susceptibility to dental caries after infection with Streptococcus mutans was studied. Rats were neonatally thymectomized (Tx) and infected with S. mutans 6715 or locally immunized with the homologous organism before infection. The Tx rats uniformly exhibited a higher level of infection with S. mutans and subsequently showed a greater extent of carious activity. Correlation studies were performed comparing the level of salivary and serum anti-S. mutans antibodies and the relative amount of dental caries. The results demonstrated that salivary immunoglobulin A antibody after immunization and infection, or infection only, showed a significant negative correlation with dental caries. Also, after local immunization, serum immunoglobulin G antibody showed a negative correlation with dental caries in the rats. These findings further support a major protective role for salivary immunoglobulin A in experimental dental caries in rats.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference31 articles.
1. Secretory IgM antibodies to Streptococcus mutans in subjects with selective IgA deficiency;Arnold R. R.;Cell. Immunol.,1977
2. Secretory immunity and immunodeficiency;Arnold R. R.;Adv. Exp. Biol. Med.,1978
3. A rapid method of grafting skin on tails of mice;Bailey D. W.;Trans. Bull.,1960
4. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation;Boyum A.;Scand. J. Clin. Lab. Invest.,1968
5. Immune dysfunction and dental caries: a preliminary report;Cole M. F.;J. Dent. Res.,1977
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献