Comparison of Versions 1.0 AND 1.5 of the UltraSensitive AMPLICOR HIV-1 MONITOR Test for Subjects with Low Viral Load-Reference-Cited by-同舟云学术

Comparison of Versions 1.0 AND 1.5 of the UltraSensitive AMPLICOR HIV-1 MONITOR Test for Subjects with Low Viral Load

Published:2004-06 Issue:6 Volume:42 Page:2774-2776
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Jackson J. Brooks¹,Piwowar-Manning Estelle¹,Johnson-Lewis LeTanya¹,Bassett Roland²,Demeter Lisa M.³,Brambilla Donald⁴

Affiliation:

1. Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287

2. SDAC, Harvard School of Public Health, Boston Massachusetts 02115-6017

3. University of Rochester Medical Center, Rochester, New York 14642

4. New England Research Institutes, Watertown, Massachusetts 02472

Abstract

ABSTRACT We compared the performance of two UltraSensitive AMPLICOR HIV-1 MONITOR kits (version 1.5 [v1.5] versus v1.0) by retesting 404 plasma samples with low viral loads (<3,000 copies/ml) with both kits. With 292 samples that initially had <50 copies/ml by the v1.0 kit, the v1.5 assay was more sensitive than the v1.0 assay for samples with human immunodeficiency virus type 1 RNA near the 50-copy/ml cutoff ( P = 0.0146). Median numbers of copies per milliliter were similar for 112 samples with 50 to 3,000 copies/ml with no difference in sensitivity with a 200-copy/ml cutoff.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.42.6.2774-2776.2004

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