Prevalence of Helicobacter pylori vacA and cagA Genotypes in Ethiopian Dyspeptic Patients-Reference-Cited by-同舟云学术

Prevalence of Helicobacter pylori vacA and cagA Genotypes in Ethiopian Dyspeptic Patients

Published:2004-06 Issue:6 Volume:42 Page:2682-2684
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Asrat Daniel¹,Nilsson Ingrid²,Mengistu Yohannes¹,Kassa Endale³,Ashenafi Senait⁴,Ayenew Kiros⁵,Wadström Torkel²,Abu-Al-Soud Waleed²

Affiliation:

1. Department of Medical Microbiology, Immunology, and Parasitology

2. Department of Medical Microbiology, Dermatology and Infection, Lund University, Lund, Sweden

3. Department of Internal Medicine

4. Department of Pathology, Faculty of Medicine, Addis Ababa University

5. Armauer Hansen Research Institute, Addis Ababa, Ethiopia

Abstract

ABSTRACT A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the s1/m1 genotype was the most common in gastric biopsy samples (48%). The vacA and cagA positive H. pylori strains were detected to a higher degree in patients with chronic active gastritis (71%) than patients with other histopathological findings (29%) ( P < 0.05).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.42.6.2682-2684.2004

Reference21 articles.

1. Abu Al-Soud, W., M. Bennedsen, S. L. W. On, I.-S. Ouis, P. Vandamme, H.-O. Nilsson, A. Ljungh, and T. Wadström. 2003. Assessment of PCR-DGGE for the identification of diverse Helicobacter species, and application to faecal samples from zoo animals to determine helicobacter prevalence. J. Med. Microbiol.52:765-771.

2. Anim, J. T., N. Al-Sobkie, A. Prasad, B. John, P. N. Sharma, and I. Al-Hamar. 2000. Assessment of different methods for staining Helicobacter pylori in endoscopic gastric biopsies. Acta Histochem.102:129-137.

3. Ashour, A. A., P. P. Magalhaes, E. N. Mendes, G. B. Collares, V. R. de Gusmao, D. M. Queiroz, A. M. Nogueira, G. A. Rocha, and C. A. de Oliveira. 2002. Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma. FEMS Immunol. Med. Microbiol.33:173-178.

4. Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori

5. Blaser, M. J., and D. E. Berg. 2001. Helicobacter pylori genetic diversity and risk of human disease. J. Clin. Investig.107:767-773.

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana;World Journal of Gastroenterology;2019-07-14

2. Infections with Helicobacter pylori and challenges encountered in Africa;World Journal of Gastroenterology;2019-07-07

3. Correlation between Helicobacter pylori Infection and Gastric Atrophy Examined in the Sera of Mongolian People;Gastrointestinal Disorders;2019-04-03

4. Association between infection with Helicobacter pylori and platelet indices among school-aged children in central Ethiopia: a cross-sectional study;BMJ Open;2019-04

5. Helicobacter pylori in Sub-Saharan Africa;Digestive Diseases in Sub-Saharan Africa;2019