Colistin Heteroresistance and Involvement of the PmrAB Regulatory System in Acinetobacter baumannii-Reference-Cited by-同舟云学术

Colistin Heteroresistance and Involvement of the PmrAB Regulatory System in Acinetobacter baumannii

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Charretier Yannick¹^ORCID,Diene Seydina M.¹,Baud Damien¹,Chatellier Sonia²,Santiago-Allexant Emmanuelle³,van Belkum Alex⁴,Guigon Ghislaine³,Schrenzel Jacques¹

Affiliation:

1. Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland

2. Innovation Unit, bioMérieux SA, La Balme Les Grottes, France

3. Innovation Unit, bioMérieux SA, Marcy l'Etoile, France

4. Data Analytics Unit, bioMérieux SA, La Balme Les Grottes, France

Abstract

Multidrug-resistant Acinetobacter baumannii infection has recently emerged as a worldwide clinical problem, and colistin is increasingly being used as a last-resort therapy. Despite its favorable bacterial killing, resistance and heteroresistance (HR) to colistin have been described.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00788-18

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