First Report of Plasmid-Mediated qnrA1 in a Ciprofloxacin-Resistant Escherichia coli Strain in Latin America

Author:

Castanheira Mariana1,Pereira Andrea S.1,Nicoletti Adriana G.1,Pignatari Antônio C. C.1,Barth Afonso L.2,Gales Ana C.1

Affiliation:

1. Laboratório ALERTA, Infectious Diseases Division, Universidade Federal de São Paulo, Sao Paolo, Brazil

2. Unidade de Microbiologia, Serviço de Patologia Clínica, Hospital de Clínicas, Porto Alegre, RS, Brazil

Abstract

ABSTRACT Among 144 ciprofloxacin-resistant Escherichia coli isolated in Brazil, one (0.69%) QnrA1-producing isolate was detected. The qnrA1 gene was associated with IS CR1 . The QnrA1 determinant was carried on a 41-kb conjugative plasmid, which also carried a FOX-type cephalosporinase encoding gene and a class 1 integron with the aadB and catB3 cassettes. This is the first report of a qnrA -carrying isolate in a Latin American country.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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