The Glycosyltransferase Gene Encoding the Enzyme Catalyzing the First Step of Mycothiol Biosynthesis ( mshA )-Reference-Cited by-同舟云学术

The Glycosyltransferase Gene Encoding the Enzyme Catalyzing the First Step of Mycothiol Biosynthesis ( mshA )

Published:2003-06 Issue:11 Volume:185 Page:3476-3479
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Newton Gerald L.¹,Koledin Teresa¹,Gorovitz Batia²,Rawat Mamta²,Fahey Robert C.¹,Av-Gay Yossef²

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093

2. Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia V5Z 3J5, Canada

Abstract

ABSTRACT Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1 d - myo -inosityl 2-acetamido-2-deoxy-α- d -glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA . The ortholog in Mycobacterium tuberculosis , Rv0486, was used to complement the mutant phenotype.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.185.11.3476-3479.2003

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