A 65-Kilobase Pathogenicity Island Is Unique to Philadelphia-1 Strains of Legionella pneumophila-Reference-Cited by-同舟云学术

A 65-Kilobase Pathogenicity Island Is Unique to Philadelphia-1 Strains of Legionella pneumophila

Published:2003-08 Issue:15 Volume:185 Page:4630-4637
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Brassinga Ann Karen C.¹,Hiltz Margot F.¹,Sisson Gary R.¹,Morash Michael G.¹,Hill Nathan¹,Garduno Elizabeth¹,Edelstein Paul H.²,Garduno Rafael A.¹³,Hoffman Paul S.¹³

Affiliation:

1. Department of Microbiology and Immunology

2. Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-4283

3. Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7

Abstract

ABSTRACT Nucleotide sequence analysis of an ∼80-kb genomic region revealed an ∼65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this ∼65-kb locus is unique to L . pneumophila serogroup 1 Philadelphia-1 strains.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.185.15.4630-4637.2003

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