Affiliation:
1. The Institute for Genomic Research, Rockville, Maryland 20850
2. Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts 02115
Abstract
ABSTRACT
The complete 2,343,479-bp genome sequence of the gram-negative, pathogenic oral bacterium
Porphyromonas gingivalis
strain W83, a major contributor to periodontal disease, was determined. Whole-genome comparative analysis with other available complete genome sequences confirms the close relationship between the
Cytophaga-Flavobacteria-Bacteroides
(CFB) phylum and the green-sulfur bacteria. Within the CFB phyla, the genomes most similar to that of
P. gingivalis
are those of
Bacteroides thetaiotaomicron
and
B. fragilis
. Outside of the CFB phyla the most similar genome to
P. gingivalis
is that of
Chlorobium tepidum
, supporting the previous phylogenetic studies that indicated that the
Chlorobia
and CFB phyla are related, albeit distantly. Genome analysis of strain W83 reveals a range of pathways and virulence determinants that relate to the novel biology of this oral pathogen. Among these determinants are at least six putative hemagglutinin-like genes and 36 previously unidentified peptidases. Genome analysis also reveals that
P. gingivalis
can metabolize a range of amino acids and generate a number of metabolic end products that are toxic to the human host or human gingival tissue and contribute to the development of periodontal disease.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
343 articles.
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