Controlled Initiation of Chromosomal Replication in Escherichia coli Requires Functional Hda Protein-Reference-Cited by-同舟云学术

Controlled Initiation of Chromosomal Replication in Escherichia coli Requires Functional Hda Protein

Published:2003-05-15 Issue:10 Volume:185 Page:3244-3248
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Camara Johanna Eltz¹,Skarstad Kirsten²,Crooke Elliott¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007

2. Department of Cell Biology, Institute for Cancer Research, Det Norske Radiumhospital, Montebello 0310, Oslo, Norway

Abstract

ABSTRACT Regulatory inactivation of DnaA helps ensure that the Escherichia coli chromosome is replicated only once per cell cycle, through accelerated hydrolysis of active replication initiator ATP-DnaA to inactive ADP-DnaA. Analysis of Δhda strains revealed that the regulatory inactivation of DnaA component Hda is necessary for maintaining controlled initiation but not for cell growth or viability.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.185.10.3244-3248.2003

Reference28 articles.

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