Trichophyton rubrum Azole Resistance Mediated by a New ABC Transporter, TruMDR3-Reference-Cited by-同舟云学术

Trichophyton rubrum Azole Resistance Mediated by a New ABC Transporter, TruMDR3

Published:2019-11 Issue:11 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Monod Michel¹,Feuermann Marc²,Salamin Karine¹,Fratti Marina¹,Makino Maya³,Alshahni Mohamed Mahdi⁴,Makimura Koichi⁴,Yamada Tsuyoshi⁵⁶

Affiliation:

1. Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

2. Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland

3. Graduate School of Health Care Science, Bunkyo Gakuin University, Tokyo, Japan

4. Graduate School of Medicine, Teikyo University, Tokyo, Japan

5. Teikyo University Institute of Medical Mycology, Tokyo, Japan

6. Asia International Institute of Infectious Disease Control, Teikyo University, Tokyo, Japan

Abstract

The mechanisms of terbinafine resistance in a set of clinical isolates of Trichophyton rubrum have been studied recently. Of these isolates, TIMM20092 also showed reduced sensitivity to azoles. The azole resistance of TIMM20092 could be inhibited by milbemycin oxime, prompting us to examine the potential of T. rubrum to develop resistance through multidrug efflux transporters.

Funder

Swiss Federal Government

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00863-19

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