Comparative Synergistic Activity of Nafcillin, Oxacillin, and Methicillin in Combination with Gentamicin Against Enterococci-Reference-Cited by-同舟云学术

Comparative Synergistic Activity of Nafcillin, Oxacillin, and Methicillin in Combination with Gentamicin Against Enterococci

Published:1975-06 Issue:6 Volume:7 Page:828-832
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Glew Richard H.,Moellering Robert C.¹,Wennersten Christine

Affiliation:

1. Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114

Abstract

The effectiveness of three semisynthetic, penicillinase-resistant penicillins alone and in combination with gentamicin was tested against 29 clinical isolates of enterococci. The minimal inhibitory concentrations of nafcillin were considerably lower than those of oxacillin and methicillin but were slightly higher than those of penicillin. At clinically achievable concentrations, the combination of nafcillin plus gentamicin produced enhanced killing against 13 of 14 strains of enterococci and was synergistic (by very rigid criteria) against 10 of 14 strains. In contrast, combinations of oxacillin plus gentamicin were synergistic against only 3 of 14 strains, and methicillin plus gentamicin produced synergistic killing against only 1 of 14 strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.7.6.828

Reference23 articles.

1. Anderson T. G. 1970. Testing of susceptibility to antimicrobial agents and assay of antimicrobial agents in body fluids p. 299-310. In J. E. Black E. H. Lennette and J. P. Truant (ed.) Manual of clinical microbiology. American Society for Microbiology Bethesda Md.

2. The group D streptococci;Deibel R. H.;Bacteriol. Rev.,1964

3. Comparison of several laboratory media for presumptive identification of enterococci and group D streptococci;Facklam R. R.;Appl. Microbiol.,1973

4. Fekety F. R. Jr. and P. Weiss. 1967. Antibiotic syner- gism: enhanced susceptibility of enterococci to combinations of streptomycin and penicillins or cephalosporins p. 156-164. Antimicrob. Agents Chemother. 1966.

5. Antibiotic synergism and antagonism: assessment of problem;Jawetz E.;Pharmacol. Rev.,1953

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