Improved Methods for Production, Isolation, and Assay of Two New Chloroisoxazoline Amino Acid Antitumor Antimetabolites: U-42,126 and U-43,795-Reference-Cited by-同舟云学术

Improved Methods for Production, Isolation, and Assay of Two New Chloroisoxazoline Amino Acid Antitumor Antimetabolites: U-42,126 and U-43,795

Published:1975-06 Issue:6 Volume:7 Page:807-810
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Haňka L. J.¹,Gerpheide S. A.¹,Spieles P. R.¹,Martin D. G.¹,Belter P. A.¹,Coleman T. A.¹,Meyer H. F.¹

Affiliation:

1. The Upjohn Company, Kalamazoo, Michigan 49001

Abstract

Improved fermentation and isolation procedures for antitumor antimetabolites U-42,126 and U-43,795 increased drug yields 30-fold. The sensitivity limit of a newly developed assay is 0.03 μg of U-42,126 and 2.0 μg of U-43,795 per ml. The in vitro antimicrobial effect of both drugs was antagonized by histidine.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.7.6.807

Reference9 articles.

1. Mechanism of action of psicofuranine;Hanika L. J.;J. Bacteriol.,1960

2. Hanika L. J. 1967. In vitro screen for antimetabolites p. 351-357. In K. H. Spitzy and H. Haschek (ed.) Proceedings of 5th international congress of chemotherapy vol.

3. International Society of Vienna.

4. U-42,126, a new antimetabolite antibiotic: production, biological activity, and taxonomy of the producing microorganism;Hanika L. J.;Antimicrob. Agents Chemother.,1973

5. Hanika L. J. J. S. Evans D. J. Mason and A. Dietz. 1967. Microbiological production of 5-azacytidine. I. Production and biological activity p. 619-624. Antimicrob. Agents Chemother. 1966.

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Crystal structure of 5-(4-tert-butoxyphenyl)-3-(4-n-octyloxyphenyl)-4,5-dihydroisoxazole;Acta Crystallographica Section E Crystallographic Communications;2019-05-24

2. Isomerization of 3-unsubstituted 4,5-dihydroisoxazoles over alumina. A new synthesis of β-hydroxy nitriles;Russian Journal of Organic Chemistry;2016-03

3. Synthesis of liquid-crystalline 3,5-diarylisoxazolines;Liquid Crystals;2010-02-10

4. The isoxazole alkaloids;The Alkaloids: Chemistry and Biology;2001

5. Stereoselective Synthesis of [2S,3R]-β-Hydroxy Ornithine;Synthetic Communications;1997-04