Affiliation:
1. Department of Microbiology, Georgetown University Schools of Medicine and Dentistry, Washington, D.C. 20007
Abstract
By use of
14
C-labeled benzyl penicillin, it has been established that β-lactamases and/or acylases play no role in the resistance of
Neisseria gonorrhoeae
to penicillin. It has been found, however, that very susceptible strains of the organisms (minimal inhibitory concentration, 0.008 μg/ml) bind 10 to 15 times as much penicillin as do moderately to highly resistant strains of the gonoccoccus (minimal inhibitory concentration, 0.125 to 2.0 μg/ml). It is postulated that this degree of change in binding components of the whole cell and whole cytoplasmic membrane is sufficient to account for the decreased susceptibility of the organism to penicillin.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
30 articles.
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