Affiliation:
1. Department of Pharmacology, College of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey 08854
Abstract
The stalked bacterium
Caulobacter bacteroides
, which displays a series of developmental changes during its life cycle, was shown to contain the methylated deoxyribonucleic acid (DNA) nucleotide bases N
6
-methyladenine and 5-methylcytosine as well as the enzymes required for the synthesis of these bases. A difference in the specific activity of these enzymes was observed between swarmer cells, which are low in activity, and stalked cells, which are high in activity. This difference was not reflected in the methylation patterns in the DNA of the two cell types since
C. bacteroides
DNA is essentially completely methylated with respect to
C. bacteroides
methylases.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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