Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice-Reference-Cited by-同舟云学术

Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice

Published:2022-10-20 Issue:10 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Shaikh Mohammad Omar Faruk¹²^ORCID,Schaefers Matthew M.¹²^ORCID,Merakou Christina¹²^ORCID,DiBlasi Marco¹^ORCID,Bonney Sarah¹,Liao Tiffany¹,Zurakowski David²³^ORCID,Kehl Margaret⁴,Tabor David E.⁴,DiGiandomenico Antonio⁴^ORCID,Priebe Gregory P.¹²⁵^ORCID

Affiliation:

1. Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA

3. Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA

4. Vaccines and Immune Therapies, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA

5. Division of Infectious Diseases, Department of Pediatrics, Boston Children’s Hospital, Boston, Massachusetts, USA

Abstract

The Gram-negative pathogen Pseudomonas aeruginosa is a common cause of pneumonia in hospitalized patients. Its increasing antibiotic resistance and widespread occurrence present a pressing need for vaccines.

Funder

U.S. Department of Defense

Boston Children's Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00203-22

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4. Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010

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