A CpxR-Regulated zapD Gene Involved in Biofilm Formation of Uropathogenic Proteus mirabilis-Reference-Cited by-同舟云学术

A CpxR-Regulated zapD Gene Involved in Biofilm Formation of Uropathogenic Proteus mirabilis

Published:2020-06-22 Issue:7 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Chen Hong-Han¹,Chang Chien-Che¹,Yuan Yu-Han¹,Liaw Shwu-Jen¹²

Affiliation:

1. Department and Graduate Institute of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

2. Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan, Republic of China

Abstract

Proteus mirabilis , a frequent uropathogen, forms extensive biofilms on catheters that are infamously difficult to treat. To explore the mechanisms of biofilm formation by P. mirabilis , we performed in vivo transposon mutagenesis. A mutant with impaired biofilm formation was isolated. The mutant was found to have Tn 5 inserted in the zapD gene, encoding an outer membrane protein of the putative type 1 secretion system ZapBCD.

Funder

Ministry of Science and Technology, Taiwan

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00207-20

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