Antibiotic-Induced Shifts in Fecal Microbiota Density and Composition during Hematopoietic Stem Cell Transplantation-Reference-Cited by-同舟云学术

Antibiotic-Induced Shifts in Fecal Microbiota Density and Composition during Hematopoietic Stem Cell Transplantation

Published:2019-09 Issue:9 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Morjaria Sejal¹²³,Schluter Jonas²⁴,Taylor Bradford P.²⁴,Littmann Eric R.⁵²,Carter Rebecca A.⁵²,Fontana Emily²,Peled Jonathan U.⁶³,van den Brink Marcel R. M.⁵⁶³,Xavier Joao B.²⁴,Taur Ying¹²³

Affiliation:

1. Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering, New York, New York, USA

2. Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering, New York, New York, USA

3. Weill Cornell Medical College, New York, New York, USA

4. Computational Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering, New York, New York, USA

5. Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering, New York, New York, USA

6. Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering, New York, New York, USA

Abstract

Dramatic microbiota changes and loss of commensal anaerobic bacteria are associated with adverse outcomes in hematopoietic cell transplantation (HCT) recipients. In this study, we demonstrate these dynamic changes at high resolution through daily stool sampling and assess the impact of individual antibiotics on those changes.

Funder

HHS | NIH | National Cancer Institute

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00206-19

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