Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques

Author:

Chan Mable1,Tiwary Meenakshi23,Wu Helen L.23,Tailor Nikesh1,Vendramelli Robert1,Audet Jonathan1,Warner Bryce M.1,Tierney Kevin1,Albietz Alix1,Truong Thang1,Doan Kaylie1,Bello Alexander1,Willman Marnie1,Griffin Bryan D.14,Hanley Patrick W.5,Lovaglio Jamie5,Safronetz David16,Strong Jim16,Sacha Jonah B.23ORCID,Kobasa Darwyn16

Affiliation:

1. Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

2. Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, USA

3. Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, USA

4. Vaccine Safety Surveillance, Immunization Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada

5. Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

6. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada

Abstract

The world remains at risk of an influenza pandemic, and the development of new therapeutic and preventative modalities is critically important for minimizing human death and suffering during the next influenza pandemic. Animal models are central to the development of new therapies and vaccine approaches.

Funder

Bill and Melinda Gates Foundation

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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