Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae-Reference-Cited by-同舟云学术

Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae

Published:2019-02 Issue:2 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Meyer Sauteur Patrick M.¹²³⁴,de Bruijn Adrianus C. J. M.¹,Graça Catarina¹,Tio-Gillen Anne P.⁵⁶,Estevão Silvia C.¹,Hoogenboezem Theo¹,Hendriks Rudi W.⁷,Berger Christoph³⁴,Jacobs Bart C.⁵⁶,van Rossum Annemarie M. C.²,Huizinga Ruth⁵,Unger Wendy W. J.¹

Affiliation:

1. Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children’s Hospital, University Medical Center, Rotterdam, The Netherlands

2. Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children’s Hospital, University Medical Center, Rotterdam, The Netherlands

3. Division of Infectious Diseases and Hospital Epidemiology, University Children’s Hospital Zurich, Zurich, Switzerland

4. Children’s Research Center, University Children’s Hospital Zurich, Zurich, Switzerland

5. Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

6. Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

7. Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

Abstract

Antibody responses to Mycoplasma pneumoniae correlate with pulmonary M. pneumoniae clearance. However, M. pneumoniae -specific IgG antibodies can cross-react with the myelin glycolipid galactocerebroside (GalC) and cause neurological disorders.

Funder

Sophia Scientific Research Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00663-18

Reference58 articles.

1. Mycoplasma pneumoniaeand Its Role as a Human Pathogen

2. The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America

3. Infection with and Carriage of Mycoplasma pneumoniae in Children