Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells

Author:

Naseer Nawar1,Zhang Jenna1,Bauer Renate23,Constant David A.2,Nice Timothy J.2ORCID,Brodsky Igor E.4ORCID,Rauch Isabella2,Shin Sunny1ORCID

Affiliation:

1. Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

2. Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA

3. Department of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria

4. Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA

Abstract

Salmonella enterica serovar Typhimurium is a Gram-negative pathogen that causes diseases ranging from gastroenteritis to systemic infection and sepsis. Salmonella uses type III secretion systems (T3SS) to inject effectors into host cells. While these effectors are necessary for bacterial invasion and intracellular survival, intracellular delivery of T3SS products also enables detection of translocated Salmonella ligands by cytosolic immune sensors.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

American Heart Association

Burroughs Wellcome Fund

Marshallplan-Jubiläumsstiftung

Oregon Health and Science University

Penn | Perelman School of Medicine, University of Pennsylvania

Universität Salzburg

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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