Staphylococcus aureus and Acinetobacter baumannii Inhibit Osseointegration of Orthopedic Implants-Reference-Cited by-同舟云学术

Staphylococcus aureus and Acinetobacter baumannii Inhibit Osseointegration of Orthopedic Implants

Published:2022-03-17 Issue:3 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Choe Hyonmin¹²^ORCID,Tatro Joscelyn M.¹,Hausman Bryan S.¹,Hujer Kristine M.³,Marshall Steve H.³,Akkus Ozan⁴,Rather Phillip N.⁵⁶,Lee Zhenghong⁷,Bonomo Robert A.³⁸⁹¹⁰¹¹^ORCID,Greenfield Edward M.¹¹²^ORCID

Affiliation:

1. Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio, USA

2. Department of Orthopaedics, Yokohama City University, Yokohama, Kanagawa, Japan

3. CWRU–Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA

4. Department of Mechanical Engineering, Case Western Reserve University, Cleveland, Ohio, USA

5. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

6. Research Service, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA

7. Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA

8. Medical Service and GRECC, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

9. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

10. Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

11. Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

12. Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA

Abstract

Bacterial infections routinely cause inflammation and thereby impair osseointegration of orthopedic implants.Acinetobacterspp., which cause osteomyelitis following trauma, on or off the battlefield, were, however, reported to cause neither osteomyelitis nor osteolysis in rodents. We therefore compared the effects ofAcinetobacterstrain M2 to those ofStaphylococcus aureusin a murine implant infection model. Sterile implants and implants with adherent bacteria were inserted in the femur of mice.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Mochida Memorial Foundation for Medical and Pharmaceutical Research

U.S. Department of Defense

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00669-21

Reference80 articles.