Using Split Luciferase Assay and Anti-Herpes Simplex Virus Glycoprotein Monoclonal Antibodies To Predict a Functional Binding Site between gD and gH/gL-Reference-Cited by-同舟云学术

Using Split Luciferase Assay and Anti-Herpes Simplex Virus Glycoprotein Monoclonal Antibodies To Predict a Functional Binding Site between gD and gH/gL

Published:2021-03-25 Issue:8 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Atanasiu Doina¹^ORCID,Saw Wan Ting¹,Cairns Tina M.¹^ORCID,Eisenberg Roselyn J.²,Cohen Gary H.¹

Affiliation:

1. Department of Basic and Translational Science, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Virus entry and cell-cell fusion mediated by HSV require four essential glycoproteins, gD, gH/gL, gB, and a gD receptor. Virus-neutralizing antibodies directed against any of these proteins bind to residues within key functional sites and interfere with essential steps in the fusion pathway.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00053-21

Reference59 articles.

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2. Fusing structure and function: a structural view of the herpesvirus entry machinery

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4. The COMPLEXity in herpesvirus entry

5. Surface Plasmon Resonance Reveals Direct Binding of Herpes Simplex Virus Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD

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