Functional Effects of Cardiomyocyte Injury in COVID-19

Author:

Siddiq Mustafa M.12ORCID,Chan Angel T.123,Miorin Lisa45,Yadaw Arjun S.12,Beaumont Kristin G.678,Kehrer Thomas459,Cupic Anastasija45,White Kris M.45,Tolentino Rosa E.12,Hu Bin12,Stern Alan D.12,Tavassoly Iman12,Hansen Jens12,Sebra Robert67810,Martinez Pedro12,Prabha Som12,Dubois Nicole117,Schaniel Christoph712,Iyengar-Kapuganti Rupa13,Kukar Nina13,Giustino Gennaro712,Sud Karan13,Nirenberg Sharon14,Kovatch Patricia614,Albrecht Randy A.45ORCID,Goldfarb Joseph12,Croft Lori13,McLaughlin Maryann A.13,Argulian Edgar13,Lerakis Stamatios13,Narula Jagat13,García-Sastre Adolfo451516ORCID,Iyengar Ravi12

Affiliation:

1. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA

2. Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

3. Department of Medicine and Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

4. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

5. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

6. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA

7. Black Family Stem Cell Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA

8. Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

9. Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA

10. Sema4, a Mount Sinai Venture, Stamford, Connecticut, USA

11. Department of Cell Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

12. Division of Hematology & Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

13. Division of Cardiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

14. Department of Scientific Computing and Data Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA

15. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

16. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

SARS-CoV-2 infects multiple organs, including the heart. Analyses of hospitalized patients show that a substantial number without prior indication of heart disease or comorbidities show significant injury to heart tissue, assessed by increased levels of troponin in blood.

Funder

CRIP Center for Research on Influenza Pathogenesis

CRIPT Center for Research on Influenza Pathogenesis and Transmission

American Heart Association

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

JPB Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference57 articles.

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