Affiliation:
1. Section on Viruses and Cellular Biology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
Abstract
We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference30 articles.
1. SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen;Bikel I.;Cell,1987
2. New region of the simian virus 40 genome required for efficient viral transformation;Bouck N.;Proc. Natl. Acad. Sci. USA,1978
3. Characterization of hamster tumors induced by simian virus 40 small t deletion mutants as true histiocytic lymphomas;Carbone M.;Cancer Res.,1989
4. Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice;Choi Y.;Mol. Cell. Biol.,1988
5. Removal of serine phosphates from simian virus 40 large T antigen increases its ability to stimulate DNA replication in vitro but has no effect on ATPase and DNA binding;Grasser F. A.;J. Virol.,1987
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献