Affiliation:
1. Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208
Abstract
ABSTRACT
Toll-like receptor 2 (TLR2) deficiency enhances murine susceptibility to infection by
Francisella tularensis
as indicated by accelerated mortality, higher bacterial burden, and greater histopathology. Analysis of pulmonary cytokine levels revealed that TLR2 deficiency results in significantly lower levels of tumor necrosis factor alpha and interleukin-6 but increased amounts of gamma interferon and monocyte chemoattractant protein 1. This pattern of cytokine production may contribute to the exaggerated pathogenesis seen in TLR2
−/−
mice. Collectively, these findings suggest that TLR2 plays an important role in tempering the host response to pneumonic tularemia.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
101 articles.
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