Affiliation:
1. National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
Abstract
The metabolism of fluorene, a tricyclic aromatic hydrocarbon, by Cunninghamella elegans ATCC 36112 was investigated. Approximately 69% of the [9-14C]fluorene added to cultures was metabolized within 120 h. The major ethyl acetate-soluble metabolites were 9-fluorenone (62%), 9-fluorenol, and 2-hydroxy-9-fluorenone (together, 7.0%). Similarly to bacteria, C. elegans oxidized fluorene at the C-9 position of the five-member ring to form an alcohol and the corresponding ketone. In addition, C. elegans produced the novel metabolite 2-hydroxy-9-fluorenone.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Reference26 articles.
1. Determination of polycyclic aromatic hydrocarbons in sediments and mussels from Saudafjord West Norway by glass capillary gas-chromatography. Sci;Bjorseth A.;Total Environ.,1979
2. Biodegradation of polycyclic aromatic hydrocarbons by Phanerochaete chrysosporium;Bumpus J. A.;Appl. Environ. Microbiol.,1989
3. Stereochemistry and evidence for an arene oxide-NIH shift pathway in the fungal metabolism of naphthalene;Cerniglia C. E.;Chem.-Biol. Interact.,1983
4. Cerniglia C. E. and M. A. Heitkamp. 1989. Microbial degradation of polycyclic aromatic hydrocarbons in the aquatic environment p. 41-63. In U. Varanasi (ed.) Metabolism of polycyclic aromatic hydrocarbons in the aquatic environment vol. 2. CRC Press Boca Raton Fla.
5. Complete 13C and 'H NMR chemical shift assignments of 1-nitropyrene;Cho B. P.;Spectrosc. Lett.,1991
Cited by
32 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献