Affiliation:
1. Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan. yyoshika@tsuru.med.nagoya-u.ac.jp
Abstract
Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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