Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells

Author:

Kaneko H1,Neoh L P1,Takeda N1,Akimoto H1,Hishikawa T1,Hashimoto H1,Hirose S1,Karaki S1,Takiguchi M1,Nakauchi H1,Kaneko Y1,Yamamoto N1,Sekigawa I1

Affiliation:

1. Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.

Abstract

We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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