Genome Sequence of a Novel HIV-1 Circulating Recombinant Form (CRF77_cpx) Identified among Blood Donors in Malaysia-Reference-Cited by-同舟云学术

Genome Sequence of a Novel HIV-1 Circulating Recombinant Form (CRF77_cpx) Identified among Blood Donors in Malaysia

Published:2017-06-29 Issue:26 Volume:5 Page:
ISSN:2169-8287
Container-title:Genome Announcements
language:en
Short-container-title:Genome Announc

Author:

Tee Kok Keng¹²,Bon Abdul Hamid³,Chow Wei Zhen²,Ng Kim Tien²,Chan Kok Gan⁴^ORCID,Kamarulzaman Adeeba²,Busch Michael P.⁵⁶,Takebe Yutaka¹⁷

Affiliation:

1. Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

2. Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

3. National Blood Centre of Kuala Lumpur (NBCKL), Kuala Lumpur, Malaysia

4. Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia

5. Blood Systems Research Institute (BSRI), San Francisco, California, USA

6. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA

7. AIDS Research Center, National Institute of Infectious Diseases, Toyama, Tokyo, Japan

Abstract

ABSTRACT We report here the first HIV-1 circulating recombinant form (CRF) complex identified among the blood donors in Malaysia. The CRF77_cpx mosaic genome consists of parental subtypes B′, C, and CRF01_AE and is structurally related to CRF07_BC. The identification of CRF77_cpx underlines the genetic complexity and mobility of HIV-1 among the blood donors.

Funder

Ministry of Education Malaysia

University of Malaya

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/genomeA.00459-17

Reference6 articles.

1. Extensive Genetic Diversity of HIV-1 in Incident and Prevalent Infections among Malaysian Blood Donors: Multiple Introductions of HIV-1 Genotypes from Highly Prevalent Countries

2. Identification of a Novel Circulating Recombinant Form (CRF33_01B) Disseminating Widely Among Various Risk Populations in Kuala Lumpur, Malaysia

3. Full-Length Human Immunodeficiency Virus Type 1 Genomes from Subtype C-Infected Seroconverters in India, with Evidence of Intersubtype Recombination

4. Characterization of a Virtually Full-Length Human Immunodeficiency Virus Type 1 Genome of a Prevalent Intersubtype (C/B′) Recombinant Strain in China

5. Nationwide Trends in Molecular Epidemiology of HIV-1 in China

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