Genetic Characterization of an Avian Influenza Virus H4N6 Strain Isolated from a Guangxi Pockmark Duck

Author:

Xie Liji1,Xie Zhixun1,Wu Aiqiong1,Luo Sisi1,Zhang Minxiu1,Huang Li1,Xie Zhiqin1,Huang Jiaoling1,Zhang Yanfang1,Zeng Tingting1,Deng Xianwen1

Affiliation:

1. Guangxi Key Laboratory of Veterinary Biotechnology, Guangxi Veterinary Research Institute, Nanning, Guangxi Province, China

Abstract

ABSTRACT An H4N6 subtype avian influenza virus was isolated from a pockmark duck in southern China in November 2013 and named A/duck/Guangxi/149D24/2013 (H4N6). All eight gene segments of the strain were sequenced. Sequence analysis indicated that this H4N6 virus was a natural reassortant virus. This H4N6 virus has two basic amino acids in the cleavage site of hemagglutinin 1 (HA1) and HA2, and the amino acid motif of cleavage site was PEKASRGLF, which is the typical characteristic of the low-pathogenic avian influenza virus. This study will help understand the epidemiology and molecular characteristics of avian influenza virus in pockmark ducks.

Funder

Guangxi science and technology bureau

National ten-thousand talents program of China

Guangxi government senior scientist foundation

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

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