Draft Genome Sequence of Escherichia coli Strain VKPM B-10182, Producing the Enzyme for Synthesis of Cephalosporin Acids-Reference-Cited by-同舟云学术

Draft Genome Sequence of Escherichia coli Strain VKPM B-10182, Producing the Enzyme for Synthesis of Cephalosporin Acids

Published:2014-12-24 Issue:6 Volume:2 Page:
ISSN:2169-8287
Container-title:Genome Announcements
language:en
Short-container-title:Genome Announc

Author:

Mardanov Andrey V.¹,Eldarov Mikhail A.¹,Sklyarenko Anna V.²,Dumina Maria V.¹,Beletsky Alexey V.¹,Yarotsky Sergey V.²,Ravin Nikolai V.¹

Affiliation:

1. Centre “Bioengineering,” Russian Academy of Sciences, Moscow, Russian Federation

2. State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russian Federation

Abstract

ABSTRACT Escherichia coli strain VKPM B-10182, obtained by chemical mutagenesis from E. coli strain ATCC 9637, produces cephalosporin acid synthetase employed in the synthesis of β-lactam antibiotics, such as cefazolin. The draft genome sequence of strain VKPM B-10182 revealed 32 indels and 1,780 point mutations that might account for the improvement in antibiotic synthesis that we observed.

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/genomeA.01222-14

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4. [54b] Penicillin acylase (bacterial)

5. THE HYDROLYSIS OF PENICILLIN G TO 6-AMINO PENICILLANIC ACID BY ENTRAPPED PENICILLIN ACYLASE

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