Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome-Reference-Cited by-同舟云学术

Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome

Published:2014-10-30 Issue:5 Volume:2 Page:
ISSN:2169-8287
Container-title:Genome Announcements
language:en
Short-container-title:Genome Announc

Author:

Yang Dongmei¹,Alam Zohaib²,Cui Xiaohong²,Chen Michael¹,Sherrod Carly J.¹,McVoy Michael A.²,Schleiss Mark R.³,Dittmer Dirk P.¹

Affiliation:

1. University of North Carolina School of Medicine, Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA

2. Virginia Commonwealth University School of Medicine, Department of Pediatrics, Richmond, Virginia, USA

3. University of Minnesota Medical School, Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Minneapolis, Minnesota, USA

Abstract

ABSTRACT The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenuation of N13R10 may arise from an inability to express GP129 and/or GP130.

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/genomeA.00928-14

Reference14 articles.

1. Cytomegaloviral Infections in the Guinea Pig: Experimental Models for Human Disease

2. Serial Propagation of the Guinea Pig Salivary Gland Virus in Tissue Culture

3. Effect of Passive Antibody on Congenital Cytomegalovirus Infection in Guinea Pigs

4. Nonprimate Models of Congenital Cytomegalovirus (CMV) Infection: Gaining Insight into Pathogenesis and Prevention of Disease in Newborns

5. Cloning the complete guinea pig cytomegalovirus genome as an infectious bacterial artificial chromosome with excisable origin of replication

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