RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells-Reference-Cited by-同舟云学术

RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells

Published:2021-06-24 Issue:14 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rahman Masmudur M.¹,Gutierrez-Jensen Ami D.¹,Glenn Honor L.,Abrantes Mario¹,Moussatche Nissin²,McFadden Grant¹^ORCID

Affiliation:

1. Center for Immunotherapy, Vaccines, and Virotherapy Biodesign Institute, Arizona State University, Tempe, Arizona, USA

2. Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA

Abstract

The cellular DHX9 has both proviral and antiviral roles against diverse RNA and DNA viruses. In this article, we demonstrate that DHX9 can form unique antiviral granules in the cytoplasm during myxoma virus (MYXV) replication in human cancer cells.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00151-21

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