Telaprevir Treatment Reduces Paralysis in a Mouse Model of Enterovirus D68 Acute Flaccid Myelitis-Reference-Cited by-同舟云学术

Telaprevir Treatment Reduces Paralysis in a Mouse Model of Enterovirus D68 Acute Flaccid Myelitis

Published:2023-05-31 Issue:5 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Frost Joshua¹^ORCID,Rudy Michael J.²,Leser J. Smith²,Tan Haozhou³,Hu Yanmei³,Wang Jun³^ORCID,Clarke Penny²^ORCID,Tyler Kenneth L.¹²⁴⁵^ORCID

Affiliation:

1. Department of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA

2. Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA

3. Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey, USA

4. Division of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA

5. Neurology Service, Rocky Mountain VA Medical Center, Aurora, Colorado, USA

Abstract

Recent outbreaks of EV-D68 in 2014, 2016, and 2018 have resulted in over 600 cases of a paralytic illness that is known as AFM. AFM is a predominantly pediatric disease with no FDA-approved treatment, and many patients show minimal recovery from limb weakness.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | OSC | Common Fund

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00156-23

Reference34 articles.

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2. C. Centers for Disease Control and Prevention, enterovirus surveillance–United States, 1970–2005;Khetsuriani N;MMWR Surveill Summ,2006