Adenovirus 5 E1A Interacts with E4orf3 To Regulate Viral Chromatin Organization-Reference-Cited by-同舟云学术

Adenovirus 5 E1A Interacts with E4orf3 To Regulate Viral Chromatin Organization

Published:2019-05-15 Issue:10 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Soriano Andrea Michelle¹,Crisostomo Leandro¹,Mendez Megan¹,Graves Drayson¹,Frost Jasmine Rae¹,Olanubi Oladunni¹,Whyte Peter F.²,Hearing Patrick³,Pelka Peter¹⁴

Affiliation:

1. Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

2. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

3. Department of Molecular Genetic & Microbiology, Stony Brook University School of Medicine, Stony Brook, New York, USA

4. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

Abstract

To successfully replicate, human adenovirus needs to carry out a rapid yet ordered transcriptional program that executes and drives viral replication. Early in infection, the viral E1A proteins are the key activators and regulators of viral transcription. Here we report, for the first time, that E1A works together with E4orf3 to perfect the viral transcriptional program and identify a novel mechanism by which the virus can adjust viral gene expression by modifying its genome’s nucleosomal organization via cooperation between E1A and E4orf3.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Research Manitoba

Cancer Research Society

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00157-19

Reference46 articles.

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