Regulation of OmpA Translation and Shigella dysenteriae Virulence by an RNA Thermometer-Reference-Cited by-同舟云学术

Regulation of OmpA Translation and Shigella dysenteriae Virulence by an RNA Thermometer

Published:2020-02-20 Issue:3 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Murphy Erin R.¹²³,Roßmanith Johanna⁴,Sieg Jacob⁵⁶,Fris Megan E.³⁷,Hussein Hebaallaha¹⁸,Kouse Andrew B.²³⁷,Gross Kevin⁶,Zeng Chunxi⁵,Hines Jennifer V.²⁵,Narberhaus Franz⁴^ORCID,Coschigano Peter W.¹²

Affiliation:

1. Department of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine, Athens, Ohio, USA

2. Molecular Cell Biology Program, Ohio University, Athens, Ohio, USA

3. Infectious and Tropical Diseases Institute, Ohio University, Athens, Ohio, USA

4. Department for Microbiology, Ruhr University Bochum, Bochum, Germany

5. Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA

6. Honors Tutorial College, Ohio University, Athens, Ohio, USA

7. Department of Biology, Ohio University, Athens, Ohio, USA

8. National Research Center, Cairo, Egypt

Abstract

RNA thermometers are cis -acting riboregulators that mediate the posttranscriptional regulation of gene expression in response to environmental temperature. Such regulation is conferred by temperature-responsive structural changes within the RNA thermometer that directly result in differential ribosomal binding to the regulated transcript. The significance of RNA thermometers in controlling bacterial physiology and pathogenesis is becoming increasingly clear.

Funder

Ohio University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00871-19

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