A high-throughput structural system biology approach to increase structure representation of proteins from <i>Clostridioides difficile</i>-Reference-Cited by-同舟云学术

A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile

Published:2023-10-19 Issue:10 Volume:12 Page:
ISSN:2576-098X
Container-title:Microbiology Resource Announcements
language:en
Short-container-title:Microbiol Resour Announc

Author:

Rosas-Lemus Monica¹²,Dey Supratim¹²,Minasov George¹²,Tan Kemin²³⁴^ORCID,Anderson Spencer M.⁵,Brunzelle Joseph⁵,Nocadello Salvatore¹²,Shabalin Ivan²⁶,Filippova Ekaterina¹²,Halavaty Andrei¹²,Kim Youngchang²³⁴,Maltseva Natalia²³⁴,Osipiuk Jerzy²³⁴,Minor Wladek²⁶,Joachimiak Andrzej²³⁴,Savchenko Alexei²⁷^ORCID,Anderson Wayne F.²⁸,Satchell Karla J. F.¹²^ORCID,

Affiliation:

1. Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

2. Center for Structural Biology of Infectious Diseases, Chicago, Illinois, USA

3. Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA

4. Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, Illinois, USA

5. Northwestern Synchrotron Research Center, Life Sciences Collaborative Access Team, Northwestern University, Argonne, Illinois, USA

6. Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA

7. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

8. Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Abstract

ABSTRACT Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Energy

Michigan Economic Development Corporation

Publisher

American Society for Microbiology

Subject

Genetics,Immunology and Microbiology (miscellaneous),Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/mra.00507-23

Reference30 articles.

1. Clostridium difficileInfection: A Worldwide Disease

2. Clostridioides difficile

3. Microbial and metabolic interactions between the gastrointestinal tract andClostridium difficileinfection

4. Clostridium difficile colitis: pathogenesis and host defence

5. Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection