Role of Peroxide in Phagocytic Killing of Pneumococci

Author:

Pitt Jane1,Bernheimer Harriet P.2

Affiliation:

1. Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032

2. Departments of Medicine and Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, New York 11203

Abstract

Two mutants of a pneumococcus type I with diminished peroxide production were selected from a population of nitrosoguanidine-treated cells. White cells of normal patients killed the mutant pneumococci as well as the otherwise isogenic wild-type strain. In patients studied with chronic granulomatous disease, however, the peroxide-poor strain was killed far less well than the wild type. These studies indicate that the removal of a peroxide-generating system in the phagocytic vacuole specifically brings forth the killing defect in chronic granulomatous disease.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference12 articles.

1. Deficiency of reduced nicotinamide-adenine dinucleotide oxidase in chronic granulomatous disease;Baehner R. L.;Science,1968

2. Leukocyte oxidase: defective activity in chronic granulomatous disease;Baehner R. L.;Science,1967

3. Correction of metabolic deficiencies in the leukocytes of patients with chronic granulomatous disease;Baehner R. L.;J. Clin. Invest.,1970

4. Interactions between rabbit polymorphonuclear leukocytes and Staphylococci;Cohn Z. A.;J. Exp. Med.,1959

5. Induction of closely linked multiple mutations by nitrosoguanidine;Guerola N.;Nature (London),1971

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