Simian Model for the Evaluation of Immunity to Influenza

Author:

Berendt Richard F.1

Affiliation:

1. U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701

Abstract

Rhesus monkeys ( Macaca mulatta ) exposed to small-particle aerosols of the Aichi strain of type A2 influenza virus responded by shedding virus from the nasopharynx for 7 to 9 days and by seroconversion (hemagglutination inhibition) 8 or 9 days after exposure. After rechallenge with the homologous virus, no replication of the organism was observed, and a serological anamnestic reaction occurred. The data indicate that the rhesus monkey is a useful primate model for evaluating induced immunity to influenza virus infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference19 articles.

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4. Decker H. M. L. M. Buchanan and C. M. Dahlgren. 1959. Sampling biological aerosols. Public Health Service Monogr. no. 60. U.S. Government Printing Office Washington D.C.

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