Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination against Botulinum C and D Neurotoxins-Reference-Cited by-同舟云学术

Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination against Botulinum C and D Neurotoxins

Published:2019-12 Issue:12 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Snow Doris M.¹,Riling Kathryn¹,Kimbler Angie²,Espinoza Yero³,Wong David³,Pham Khanh³,Martinez Zachary³,Kraus Carl N.⁴,Conrad Fraser⁵,Garcia-Rodriguez Consuelo⁵,Cobb Ronald R.²,Marks James D.⁵,Tomic Milan T.³

Affiliation:

1. Ology Bioservices, Inc., Frederick, Maryland, USA

2. Ology Bioservices, Inc., Alachua, Florida, USA

3. Ology Bioservices, Inc., Berkeley, California, USA

4. Arrevus, Raleigh, North Carolina, USA

5. Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA

Abstract

Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as tier 1 biothreat agents due to their high potency and lethality. The existence of seven BoNT serotypes (A to G), which differ by 35% to 68% in amino acid sequences, necessitates the development of serotype-specific countermeasures.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01270-19

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