Evolution of the Helicobacter pylori Vacuolating Cytotoxin in a Human Stomach-Reference-Cited by-同舟云学术

Evolution of the Helicobacter pylori Vacuolating Cytotoxin in a Human Stomach

Published:2004-08 Issue:15 Volume:186 Page:5182-5185
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Aviles-Jimenez Francisco¹,Letley Darren P.¹,Gonzalez-Valencia Gerardo²,Salama Nina³,Torres Javier²,Atherton John C.¹

Affiliation:

1. Wolfson Digestive Diseases Centre and Institute of Infection, Immunity and Inflammation, University of Nottingham, University Hospital, Nottingham NG7 2UH, United Kingdom

2. Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico

3. Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington

Abstract

ABSTRACT We describe two subclones of Helicobacter pylori , isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA , but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.186.15.5182-5185.2004

Reference26 articles.

1. Achtman, M., T. Azuma, D. E. Berg, Y. Ito, G. Morelli, Z. J. Pan, S. Suerbaum, S. A. Thompson, A. van der Ende, and L. J. van Doorn. 1999. Recombination and clonal groupings within Helicobacter pylori from different geographical regions. Mol. Microbiol. 32 : 459-470.

2. Akopyanz, N., N. O. Bukanov, T. U. Westblom, S. Kresovich, and D. E. Berg. 1992. DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting. Nucleic Acids Res. 20 : 5137-5142.

3. Atherton, J. C. 1997. The clinical relevance of strain types of Helicobacter pylori. Gut 40 : 701-703.

4. Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori

5. Simple and Accurate PCR-Based System for Typing Vacuolating Cytotoxin Alleles of Helicobacter pylori

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