De Novo Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in Mycobacterium smegmatis-Reference-Cited by-同舟云学术

De Novo Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in Mycobacterium smegmatis

Published:2021-03-08 Issue:7 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Kipkorir Terry¹^ORCID,Mashabela Gabriel T.¹,de Wet Timothy J.¹²,Koch Anastasia¹,Dawes Stephanie S.¹,Wiesner Lubbe³^ORCID,Mizrahi Valerie¹⁴,Warner Digby F.¹⁴^ORCID

Affiliation:

1. SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, DSI/NRF Centre of Excellence for Biomedical TB Research, University of Cape Town, Cape Town, South Africa

2. Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

3. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

4. Wellcome Centre for Infectious Diseases Research in Africa, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

Abstract

Alterations in cobalamin-dependent metabolism have marked the evolution of Mycobacterium tuberculosis into a human pathogen. However, the role(s) of cobalamin in mycobacterial physiology remain poorly understood.

Funder

Howard Hughes Medical Institute

National Research Foundation

South African Medical Research Council

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00620-20

Reference63 articles.

1. Comparative Genomics of the Vitamin B12 Metabolism and Regulation in Prokaryotes