Bioavailability of Aciclovir after Oral Administration of Aciclovir and Its Prodrug Valaciclovir to Patients with Leukopenia after Chemotherapy-Reference-Cited by-同舟云学术

Bioavailability of Aciclovir after Oral Administration of Aciclovir and Its Prodrug Valaciclovir to Patients with Leukopenia after Chemotherapy

Published:2000-01 Issue:1 Volume:44 Page:207-209
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Steingrimsdottir Hlif¹,Gruber Astrid¹,Palm Carina²,Grimfors Gunnar¹,Kalin Mats³,Eksborg Staffan²

Affiliation:

1. Department of Medicine, Division of Hematology,1

2. Karolinska Pharmacy,2 Karolinska Hospital, SE-171 76 Stockholm, Sweden

3. Division of Infectious Diseases,3 and

Abstract

ABSTRACT The median bioavailabilities of aciclovir after administration of aciclovir and its prodrug valaciclovir were 21.5 and 70.1%, respectively, in 12 patients with malignant hematological diseases with leukopenia after chemotherapy. The interindividual variations of the bioavailability were 48.5 and 21.0% after administration of aciclovir and valaciclovir, respectively. Neither the bioavailability nor the interindividual variation of area under the concentration-time curve of oral aciclovir or valaciclovir differed from that reported in healthy volunteers.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.1.207-209.2000

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