Multiple-Antibiotic Resistance Mediated by Structurally Related IncL/M Plasmids Carrying an Extended-Spectrum β-Lactamase Gene and a Class 1 Integron-Reference-Cited by-同舟云学术

Multiple-Antibiotic Resistance Mediated by Structurally Related IncL/M Plasmids Carrying an Extended-Spectrum β-Lactamase Gene and a Class 1 Integron

Published:2000-10 Issue:10 Volume:44 Page:2911-2914
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Villa Laura¹,Pezzella Cristina¹,Tosini Fabio²,Visca Paolo³⁴,Petrucca Andrea¹,Carattoli Alessandra¹

Affiliation:

1. Laboratory of Bacteriology and Medical Mycology1 and

2. Laboratory of Cellular Biology,2 Istituto Superiore di Sanità,

3. Dipartimento di Biologia, Università di Roma Tre,3 and

4. IRCCS Lazzaro Spallanzani,4 Rome, Italy

Abstract

ABSTRACT A conjugative IncL/M plasmid (pSEM) conferring resistance to gentamicin, amikacin, kanamycin, sulfonamides, and expanded-spectrum cephalosporins was found in pathogenic strains of Salmonella enterica serotype Typhimurium. Resistance to aminoglycosides was encoded by a sul1 -type class 1 integron (In-t3). An extended-spectrum beta-lactamase gene, bla SHV-5 , was identified 3.5 kb downstream of the integrase ( intI1 ) gene of In-t3. Nucleotide sequence analysis of the 5.3-kb bla SHV-5 –In-t3 region of pSEM highlighted striking similarities with IncL/M plasmids isolated from nosocomial gram-negative pathogens, conferring resistance to expanded-spectrum cephalosporins and aminoglycosides.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.10.2911-2914.2000

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