Thrombin-Induced Platelet Microbicidal Protein Susceptibility Phenotype Influences the Outcome of Oxacillin Prophylaxis and Therapy of Experimental Staphylococcus aureus Endocarditis-Reference-Cited by-同舟云学术

Thrombin-Induced Platelet Microbicidal Protein Susceptibility Phenotype Influences the Outcome of Oxacillin Prophylaxis and Therapy of Experimental Staphylococcus aureus Endocarditis

Published:2000-11 Issue:11 Volume:44 Page:3206-3209
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dhawan V. K.¹²,Bayer A. S.²³,Yeaman M. R.²³

Affiliation:

1. Division of Infectious Diseases, Charles Drew University-Martin Luther King Medical Center, Los Angeles, California 900591;

2. UCLA School of Medicine, Los Angeles, California 900242; and

3. Division of Adult Infectious Diseases and St. John's Cardiovascular Research Center, Harbor-UCLA Medical Center, Torrance, California 905093

Abstract

ABSTRACT We previously showed that in vitro susceptibility profiles of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 (tPMP-1) impacted the outcome of vancomycin treatment in experimental infective endocarditis. In this same model, treatment with oxacillin (a more rapid staphylocidal agent than vancomycin) enhanced the clearance of both tPMP-1-susceptible and -resistant cells from vegetations. The extent of clearance was greater for tPMP-1-susceptible cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.11.3206-3209.2000

Reference25 articles.

1. In Vitro Resistance to Thrombin-Induced Platelet Microbicidal Protein among Clinical Bacteremic Isolates of Staphylococcus aureus Correlates with an Endovascular Infectious Source

2. Chemoprophylactic efficacy against experimental endocarditis caused by beta-lactamase-producing, aminoglycoside-resistant enterococci is associated with prolonged serum inhibitory activity

3. Successful prophylaxis of experimental streptococcal endocarditis with single-dose amoxicillin administered after bacterial challenge.;Berney P.;J. Infect. Dis.,1990

4. Therapeutic significance of penicillin tolerance in experimental streptococcal endocarditis

5. Binding affinity for penicillin-binding protein 2a correlates with in vivo activity of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus.;Chambers H. F.;J. Infect. Dis.,1990

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Long-term methicillin-resistant Staphylococcus aureus bacteremia persisting for more than 2 weeks: risk factors and outcomes;European Journal of Clinical Microbiology & Infectious Diseases;2019-12-23

2. The Role of Platelets in Antimicrobial Host Defense;Platelets;2019

3. Frequency and Distribution of Single-Nucleotide Polymorphisms withinmprFin Methicillin-Resistant Staphylococcus aureus Clinical Isolates and Their Role in Cross-Resistance to Daptomycin and Host Defense Antimicrobial Peptides;Antimicrobial Agents and Chemotherapy;2015-06-08

4. Antimicrobial Host Defense;Platelets;2013

5. Comparative effectiveness of nafcillin or cefazolin versus vancomycin in methicillin-susceptible Staphylococcus aureus bacteremia;BMC Infectious Diseases;2011-10-19