Affiliation:
1. Molecular Microbiology Unit1 and
2. Department of Infectious Diseases,2 Women's and Children's Hospital, North Adelaide, South Australia 5006, Australia
Abstract
ABSTRACT
Enterococcus faecalis
strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 μg/ml) and full susceptibility to teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal vancomycin resistance genotypes (
vanA
,
vanB
,
vanC
,
vanD
, and
vanE
). We have isolated and sequenced a novel putative vancomycin resistance locus (designated
vanG
), which contains seven open reading frames, from this strain. These are organized differently from those of all the other enterococcal
van
loci, and, furthermore, the individual
vanG
gene products exhibit less than 50% amino acid sequence identity to other
van
gene products.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
152 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献