Effect of Ceftazidime on Systemic Cytokine Concentrations in Rats-Reference-Cited by-同舟云学术

Effect of Ceftazidime on Systemic Cytokine Concentrations in Rats

Published:2000-11 Issue:11 Volume:44 Page:3217-3219
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alkharfy Khalid M.¹,Kellum John A.²³,Frye Reginald F.¹⁴,Matzke Gary R.¹³⁴

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy,1

2. Departments of Anesthesiology/Critical Care Medicine2 and

3. Medicine,3 School of Medicine, and

4. Center for Clinical Pharmacology,4University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

ABSTRACT The effect of a single dose of ceftazidime on circulating concentrations of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in a rat model of sepsis was studied. IL-6 concentrations were significantly elevated (100 to 200 times the baseline) 6 h after ceftazidime administration in both septic and nonseptic (control) rats. TNF-α concentrations increased significantly in nonseptic (∼40 times the baseline) rats but not septic (∼2 to 3 times the baseline) rats. Ceftazidime administration was not associated with an increase in endotoxin concentrations. These findings suggest that ceftazidime modulation of proinflammatory cytokine concentrations may be independent of its antimicrobial properties.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.11.3217-3219.2000

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